Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome

Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis.

OBJECTIVE We synthesized the epidemiologic evidence concerning selective serotonin reuptake inhibitor (SSRI) exposure and the risk of CNS hemorrhage. METHODS We searched for controlled observational studies comparing SSRI therapy with a control group not receiving SSRIs. We used DerSimonian and Laird fixed effect models to compute summary risk associations. RESULTS Intracranial hemorrhage w...

Selective Serotonin Reuptake Inhibitors

It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt ...

Selective serotonin reuptake inhibitors.

selective serotonin reuptake inhibitors and cardiovascular events: a systematic review

background: given the importance of the role of depression in predicting the outcome of cardiovascular disorders, current medications for treating depression, particularly selective serotonin reuptake inhibitors (ssris), are taken into  consideration. this study aimed to systematically review the published findings in the use of ssris and the risk for cardiac events. materials and methods: an i...

Selective serotonin reuptake inhibitors and risk of hemorrhagic stroke.

BACKGROUND AND PURPOSE Selective serotonin reuptake inhibitors (SSRI) are widely prescribed. Several reports have observed an increased bleeding risk associated with SSRI use, which is hypothesized to be secondary to their antiplatelet effect. METHODS We tested the hypothesis that SSRIs increase the risk for or potentiate the risk of hemorrhagic stroke associated with antiplatelets and antico...